Cibinetide (ARA290) is an EPO-derivative, acting as a specific agonist of erythropoietin\/CD131 heteroreceptor, and used for neurological disease treatment.<\/p>\n
In Vitro Studies<\/p>\n
Cibinetide (ARA290) enhances proliferation, migration, and resistance to H2O2-induced apoptosis in endothelial colony-forming cells (ECFCs)[1]. Cibinetide (ARA290) is an EPO-like peptide without hematopoietic side effects, but may have neurotrophic and antidepressant effects[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.<\/p>\n
In Vivo Studies<\/p>\n
After ECFC transplantation into CLI mice, a single injection of Cibinetide (ARA290) increased the ischemia\/non-ischemia ratio of hindlimb blood flow and capillary density 28 days later and homered radiolabeled transplanted cells to the ischemic leg 4 hours post-transplantation [1].<\/p>\n
Cibineetide (ARA290; 30 \u03bcg\/kg, sc) prevented progressive deterioration of glucose control without affecting rat body weight. Cibinetide significantly reduced glucose AUC in IPGTT of GK rats [2].<\/p>\n
Low-dose Cibinetide (35 \u03bcg\/kg, ip) treatment only slightly reduced the severity of EAE in rats. Cibinetide treatment (70 \u03bcg\/kg, ip) significantly delayed the onset of EAE, reduced neurological severity, and shortened the duration of EAE in a dose-dependent manner [3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.<\/p>\n","protected":false},"excerpt":{"rendered":"
Cibinetide (ARA290) \u00e9 um derivado de EPO, atuando como um agonista espec\u00edfico do heterorreceptor eritropoietina\/CD131, e utilizado no tratamento de doen\u00e7as neurol\u00f3gicas.<\/p>","protected":false},"featured_media":3779,"template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":""},"product_brand":[],"product_cat":[35,37],"product_tag":[],"class_list":{"0":"post-3762","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptide-kit","7":"product_cat-shop-productsnew","9":"first","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3762","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3762\/revisions"}],"predecessor-version":[{"id":3782,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3762\/revisions\/3782"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/media\/3779"}],"wp:attachment":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/media?parent=3762"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_brand?post=3762"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_cat?post=3762"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_tag?post=3762"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}