GHRP-2 is a synthetic agonist of ghrelin, the newly-discovered gut peptide which binds to the growth hormone (GH) secretagogue receptor. Ghrelin has been shown to have two major effects, stimulating both GH secretion and appetite\/meal initiation. GHRP-2 has been extensively studied for its utility as a growth hormone secretagogue (GHS). Animal studies have shown its effect on food intake. However, whether GHRP-2 can also stimulate appetite in humans when administered acutely is not known. We subcutaneously infused 7 lean, healthy males with GHRP-2 (1\u03bcg\/kg\/h) or saline for 270 minutes and then measured their intake of an ad libitum, buffet-style meal. Similar to what has been reported for ghrelin administration, our subjects ate 35.9\u00b110.9 % more when infused with GHRP-2 vs. saline, with every subject increasing their intake even when calculated per kg body weight (136.0\u00b113.0 kJ\/kg vs 101.3\u00b110.5 kJ\/kg, p=0.008). The macronutrient composition of consumed food was not different between conditions. As expected, serum GH levels rose significantly during GHRP-2 infusion (AUC 5550\u00b11090 \u03bcg\/L\/240 min vs. 412\u00b1161 \u03bcg\/L\/240 min, p=0.003). These data are the first to demonstrate that GHRP-2, like ghrelin, increases food intake, suggesting that GHRP-2 is a valuable tool for investigating ghrelin effects on eating behavior in humans.<\/p>","protected":false},"excerpt":{"rendered":"
GHRP-2 \u00e9 um agonista sint\u00e9tico da grelina, o pept\u00eddeo intestinal recentemente descoberto que se liga ao receptor secretagogo de horm\u00f4nio do crescimento (GH). A grelina demonstrou ter dois efeitos principais, estimulando tanto a secre\u00e7\u00e3o de GH quanto o in\u00edcio do apetite\/refei\u00e7\u00e3o<\/p>","protected":false},"featured_media":3436,"template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":""},"product_brand":[],"product_cat":[35,37],"product_tag":[],"class_list":{"0":"post-3754","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptide-kit","7":"product_cat-shop-productsnew","9":"first","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3754","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3754\/revisions"}],"predecessor-version":[{"id":3775,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3754\/revisions\/3775"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/media\/3436"}],"wp:attachment":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/media?parent=3754"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_brand?post=3754"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_cat?post=3754"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_tag?post=3754"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}