{"id":3684,"date":"2025-11-28T03:13:12","date_gmt":"2025-11-28T03:13:12","guid":{"rendered":"https:\/\/huataipeptide.com\/?post_type=product&#038;p=3684"},"modified":"2026-05-15T15:02:13","modified_gmt":"2026-05-15T15:02:13","slug":"hgh-frag176-191","status":"publish","type":"product","link":"https:\/\/huataipeptide.com\/pt\/product\/hgh-frag176-191\/","title":{"rendered":"HGH Frag176-191"},"content":{"rendered":"<p>HGH Fragment 176\u2013191 (also known as hGH Frag 176\u2013191, Frag 176\u2013191, or AOD-9604) is a synthetic peptide derived from the C-terminal end of human growth hormone (hGH). It is primarily studied for its potential effects on\u00a0<strong class=\"Yjhzub\" data-complete=\"true\" data-processed=\"true\">fat metabolism and body weight regulation<\/strong>, and is generally intended for\u00a0<strong class=\"Yjhzub\" data-complete=\"true\" data-processed=\"true\">research use only<\/strong>, not for human consumption.<span class=\"uJ19be notranslate\" data-wiz-uids=\"jfW7Kc_e,jfW7Kc_f,jfW7Kc_g\" data-complete=\"true\" data-processed=\"true\"><span class=\"vKEkVd\" data-animation-atomic=\"\" data-sae=\"\">\u00a0<\/span><\/span><\/p>\n<section id=\"s2001\">\n<h3 class=\"pmc_sec_title\">Introduction<\/h3>\n<p>Numerous drugs with potent toxicity against cancer cells are available for treating malignancies, but therapeutic efficacies are limited due to their inefficient tumor targeting and deleterious effects on non-cancerous tissue. Therefore, two improvements are mandatory for improved chemotherapy 1) novel delivery techniques that can target cancer cells to deliver anticancer drugs and 2) methods to specifically enhance drug efficacy within tumors. The loading of inert drug carriers with anticancer agents and peptides which are able to bind (target) tumor-related proteins to enhance tumor drug accumulation and local cytotoxicity is a most promising approach.<\/p>\n<\/section>\n<section id=\"s2002\"><\/section>\n<section id=\"s2003\">&nbsp;<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Os pept\u00eddeos sint\u00e9ticos correspondentes aos amino\u00e1cidos 172-191, 176-191, 177-191, 178-191, 179-191 e 180-191 do horm\u00f4nio do crescimento humano (hGH) foram estudados pelos seus efeitos in vivo em ratos normais. Quatro dos pept\u00eddeos (hGH 172-191, 176-191, 177-191 e 178-191) produziram um aumento de curta dura\u00e7\u00e3o na glicose sangu\u00ednea e um aumento mais sustentado na insulina plasm\u00e1tica, enquanto os outros dois (hGH 179-191 e 180-191) foram inertes nos sistemas testados. Uma dose \u00fanica (5 nmol\/kg de peso corporal) dos pept\u00eddeos contendo a sequ\u00eancia de amino\u00e1cidos 178-191 da mol\u00e9cula de hGH reduziu significativamente a sensibilidade \u00e0 insulina dos animais em testes de toler\u00e2ncia \u00e0 insulina intravenosa. Os resultados tamb\u00e9m indicam que os pept\u00eddeos biologicamente ativos n\u00e3o devem apenas ter a sequ\u00eancia informacional m\u00ednima, mas tamb\u00e9m que esta deve estar na configura\u00e7\u00e3o f\u00edsica correta.<\/p>","protected":false},"featured_media":3446,"template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":""},"product_brand":[],"product_cat":[35,37],"product_tag":[],"class_list":{"0":"post-3684","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptide-kit","7":"product_cat-shop-productsnew","9":"first","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":1,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3684\/revisions"}],"predecessor-version":[{"id":3728,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3684\/revisions\/3728"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/media\/3446"}],"wp:attachment":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/media?parent=3684"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_brand?post=3684"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_cat?post=3684"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_tag?post=3684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}