{"id":3637,"date":"2025-11-28T02:42:07","date_gmt":"2025-11-28T02:42:07","guid":{"rendered":"https:\/\/huataipeptide.com\/?post_type=product&p=3637"},"modified":"2026-05-15T15:03:50","modified_gmt":"2026-05-15T15:03:50","slug":"3637","status":"publish","type":"product","link":"https:\/\/huataipeptide.com\/pt\/product\/3637\/","title":{"rendered":"Epitalon"},"content":{"rendered":"

Over 50 years ago, in 1973, the term Epithalamin was used for the first time in widely accessible scientific research. It describes a pineal polypeptide extract from cattle, which has been found to have unique properties in in vitro and in vivo experiments [1<\/a>]. The discovery of the bioactivity of this extract and its first research were mainly led by V.K Khavinson and V.N Anisimov [2<\/a>]. Since then, Epithalamin has been widely studied, including in clinical trials, showing a normalizing effect on the basic functions of the human organism and, as a result, establishing it as a geroprotective agent [3<\/a>]. Despite the publication of several reviews of Epithalamin [4<\/a>,5<\/a>,6<\/a>,7<\/a>], to the best of our knowledge, none specifically concentrate on Epitalon.<\/p>\n

Epitalon, also known as Epithalon or Epithalone, is a tetrapeptide that was developed on the basis of the amino acids composition of Epithalamin [8<\/a>]. For many years, the presence of Epitalon in the human body remained unconfirmed, until 2017, when it was detected for the first time in physiological pineal gland extract [9<\/a>]. This explains why Epitalon has similar properties to Epithalamin, but differs in the intensity of some actions [10<\/a>,11<\/a>]. It should be noted that some authors do not use this common name of Epitalon and refer only to its primary structure\u2014AEDG. This name highlights the fact that Epitalon is a tetrapeptide consisting of Ala-Glu-Asp-Gly (AEDG) amino acids bound through \u03b1-peptide bonds (Figure 1<\/a>a). Interestingly, in one article, where the antioxidant properties of Epitalon were investigated, the authors presented a different chemical structure of Epitalon, composed of the same amino acids but bonded in a different way [12<\/a>]. In this work, the peptide bond between glutamic acid and aspartic acid was through the \u03b4-carboxylic group and the peptide bond between aspartic acid and glycine was made by the \u03b3-carboxylic group (Figure 1<\/a>b). The authors named this variant of Epitalon Ala\u2014\u03b3 Glu\u2014\u03b3 Asp\u2014Gly, which indicates a potential naming mistake. However, this structure of \u201cdouble-gamma bonded\u201d Epitalon is rather an exception, as we have not encountered it in any other of the published works.<\/p>\n","protected":false},"excerpt":{"rendered":"

Epitalon, tamb\u00e9m conhecido como Epithalon ou Epithalone, \u00e9 um tetrap\u00e9ptido, Ala-Glu-Asp-Gly (AEDG), que foi sintetizado com base na composi\u00e7\u00e3o de amino\u00e1cidos do Epithalamin, um extrato da gl\u00e2ndula pineal bovina, antes de sua descoberta na solu\u00e7\u00e3o de complexo de polipept\u00eddeos da gl\u00e2ndula pineal. Nos \u00faltimos 25 anos, este composto tem sido extensivamente estudado usando m\u00e9todos in vitro, in vivo e in silico. Os resultados desses estudos indicam efeitos geroprotetores e neuroend\u00f3crinos significativos do Epitalon, resultantes de seus efeitos antioxidantes, neuroprotetores e antimutag\u00eanicos, originados tanto de mecanismos espec\u00edficos quanto n\u00e3o espec\u00edficos. Embora tenha sido demonstrado que o Epitalon exerce, entre outros efeitos, uma influ\u00eancia direta na s\u00edntese de melatonina, altera os n\u00edveis de mRNA de interleucina-2, modula a atividade mitog\u00eanica dos tim\u00f3citos murinos e aumenta a atividade de v\u00e1rias enzimas, incluindo AChE, BuChE e telomerase, permanece incerto se esses s\u00e3o os \u00fanicos mecanismos de a\u00e7\u00e3o deste composto. Al\u00e9m disso, apesar do volume consider\u00e1vel de pesquisa sobre as caracter\u00edsticas biol\u00f3gicas e farmacodin\u00e2micas do Epitalon, a quantidade de investiga\u00e7\u00f5es f\u00edsico-qu\u00edmicas e estruturais deste pept\u00eddeo permanece bastante limitada. Esta revis\u00e3o visa concluir as descobertas mais importantes desses estudos, apresentando assim o estado atual do conhecimento sobre o Epitalon.<\/p>","protected":false},"featured_media":3433,"template":"","meta":{"_seopress_robots_primary_cat":"","_seopress_titles_title":"","_seopress_titles_desc":"","_seopress_robots_index":""},"product_brand":[],"product_cat":[35,37],"product_tag":[],"class_list":{"0":"post-3637","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-peptide-kit","7":"product_cat-shop-productsnew","9":"first","10":"instock","11":"shipping-taxable","12":"purchasable","13":"product-type-variable"},"_links":{"self":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3637","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/types\/product"}],"version-history":[{"count":2,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3637\/revisions"}],"predecessor-version":[{"id":3957,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product\/3637\/revisions\/3957"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/media\/3433"}],"wp:attachment":[{"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/media?parent=3637"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_brand?post=3637"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_cat?post=3637"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/huataipeptide.com\/pt\/wp-json\/wp\/v2\/product_tag?post=3637"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}